Medicinal Chemistry & Drug Design Journals

A top-ranked review journal publishing timely, authoritative critical reviews on medicinal chemistry and related fields. Authors are recognized leaders contributing analyses of emerging drug classes, novel mechanisms of action, disease-specific therapeutic approaches, pharmacology of chemical entities, and critical assessment of the current drug discovery landscape.

The flagship ACS journal for medicinal chemistry, publishing original research on the design, synthesis, and biological evaluation of small molecules with therapeutic potential. Focus areas include structure-activity relationships (SAR), lead optimization, ADMET profiling, target engagement, covalent inhibitors, chemical probes for biological target elucidation, and computational drug design.

Covers all aspects of medicinal chemistry including synthesis, biological evaluation, SAR studies, QSAR, molecular modeling, drug-receptor interactions, and molecular aspects of drug metabolism. Accepts original papers, short communications, laboratory notes, and invited reviews from global authors on any disease target.

Publishes expert reviews of recent pharmaceutical patent claims, providing critical opinion on the scientific significance and future development potential of patented compounds, technologies, and mechanisms. Coverage includes patent analysis in oncology, antiviral, CNS, anti-inflammatory, metabolic, and cardiovascular drug discovery, plus IP landscape and patent strategy analysis.

An open-access journal focused on enzyme inhibitors, inhibitory processes, and agonist/antagonist receptor interactions in the context of medicinal and anti-cancer agent development. Covers enzymology, cell biology, chemical biology, pharmacology applied to drug design, molecular recognition, and distribution and metabolism of bioactive compounds.

A rapid-communication ACS journal for original advances in medicinal chemistry, including compound design and optimization, SAR studies, biological evaluation, drug delivery chemistry, imaging agents, pharmacology of small and large bioactive molecules, cheminformatics, and drug interactome studies. Emphasizes brevity and high novelty of findings.

Covers molecular diversity and combinatorial chemistry applied to drug discovery, including library design, virtual screening, cheminformatics, QSAR modelling, multi-objective optimization, and diversity-oriented synthesis. Publishes research on computational and experimental approaches for generating and evaluating novel bioactive compound libraries.

A broad-scope chemistry journal publishing original research across synthetic organic, inorganic, physical, theoretical, and biological chemistry. Medicinal chemistry contributions include bioactive molecule synthesis, supramolecular chemistry for drug delivery, metal-organic frameworks with biological relevance, bioinorganic chemistry, and total synthesis of bioactive natural products.

Publishes significant advances in medicinal chemistry and related drug discovery science, requiring manuscripts to demonstrate breakthrough or substantial advance over prior work. Scope includes design and synthesis of novel chemical entities and biotherapeutic modalities, SAR elucidation, discovery of new targets and modes of action, and chemical biology tools used in drug discovery.

Publishes comprehensive reviews and original research on all aspects of medicinal chemistry and rational drug design. Covers emerging therapeutic targets, drug leads and candidates, heterocyclic pharmacology, molecular modeling in drug design, anti-infective chemistry, and advances in central nervous system and cardiovascular drug research.

A Chemistry Europe journal covering medicinal chemistry and related drug discovery fields, including design and synthesis of drug candidates, SAR, computational chemistry, chemical biology, and quantitative pharmacophore modeling. Publishes research on small molecule drugs, biologically active natural products, chemical probes, and methods for QSAR analysis.

Provides a platform for original research and expert reviews on emerging drug targets, novel synthetic strategies, ADMET optimization, and the integration of computational methods into drug discovery pipelines. Covers small molecule therapeutics, biotherapeutics, and innovative delivery-oriented chemical design in the context of future pharmaceutical R&D.

Publishes research at the molecular interface of chemistry and biology, including medicinal chemistry, chemical biology, and drug discovery. Covers target identification and validation, SAR of bioactive compounds, bioinorganic chemistry, molecular recognition, carbohydrate and peptide chemistry relevant to drug design, and biotherapeutics such as antibody-drug conjugates.

Publishes thematic reviews on all areas of medicinal chemistry, with focus on particular drug classes, therapeutic targets, or methodological advances. Thematic coverage includes anticancer drug design, anti-infective agents, CNS pharmacology, drug design methodologies such as computational and fragment-based approaches, and emerging therapeutic modalities.

Publishes reviews on novel molecular targets for drug design and therapeutic intervention, covering a broad range of disease areas including cardiovascular, oncology, CNS, infectious disease, and metabolic disorders. Emphasis on target characterization, validation, and the medicinal chemistry strategies used to modulate them therapeutically.

Publishes concise, focused mini-reviews on important aspects of medicinal chemistry including drug design, SAR, in silico methods, and pharmacological evaluation. Topics span anticancer, anti-infective, anti-inflammatory, and CNS-active compound classes, providing condensed knowledge updates for practising medicinal chemists and pharmacologists.

Publishes short research communications of outstanding significance on topics at the chemistry-biology interface, emphasizing rapid dissemination of new medicinal chemistry findings. Reports novel bioactive compounds, first-in-class entities, and significant SAR advances for established or new disease targets, including computational data closely linked to experimental results.

Covers developments in medicinal chemistry, pharmacology, molecular biology, and biochemistry of molecular targets for CNS and neurological disorders, including Alzheimer's disease, Parkinson's disease, epilepsy, schizophrenia, and pain. Publishes reviews on novel drug targets such as disease-specific proteins, receptors, enzymes, and genes implicated in neurological disease.

Dedicated to publishing original research on the synthesis, properties, and reactions of heterocyclic compounds, with emphasis on medicinal chemistry applications. Covers synthesis of N-, O-, S-containing heterocycles, heterocycle functionalization, biological evaluation of heterocyclic compounds, reaction mechanisms, and total synthesis of natural heterocycles.

Focuses on all aspects of the discovery of anti-cancer agents in medicinal chemistry, including novel synthesis, biological evaluation, drug targeting, molecular modeling, and drug repositioning for cancer. Covers rational drug design against oncology targets such as kinases, HDAC, topoisomerases, immune checkpoint molecules, and tubulin.

Publishes research on synthesis and biological evaluation of compounds with therapeutic potential across a broad range of disease targets. Topics include heterocyclic synthesis, QSAR, anticancer drug design, anti-infective chemistry, anti-inflammatory compounds, CNS drug design, molecular docking, and pharmacological screening of novel chemical entities.

An international journal for rapid communications and accounts in synthetic organic chemistry. Covers novel synthetic methods, total synthesis of bioactive natural products, catalysis, reaction mechanisms, organocatalysis, and synthetic strategies applicable to the preparation of pharmacologically relevant compounds and materials.

A letter-format journal for short, rapid communications on drug design and drug discovery research. Topics include synthesis and biological evaluation of novel leads, molecular docking, SAR communications, ADMET profiling, and early discovery results against cancer, infectious disease, and CNS targets, with emphasis on preliminary novel findings.